Organocatalytic total synthesis of bioactive compounds based on one-pot methodologies

Abstract The combination of one-pot methodologies to asymmetric organocatalysis allow a green and direct access many types complex highly functionalized chiral products, including important key intermediates in total syntheses bioactive compounds. A series organocatalysts have already been successfully applied such syntheses. This report collects major developments the synthesis biologically active products based on use enantioselective organocatalytic domino/tandem reactions as steps. It is divided into two parts dealing successively with proline-derived catalysts other organocatalysts.